High-dose stereotactic radiosurgery for large brainstem metastasis and its recurrence treatment

Background. Breast cancer contributed to 11.8 % of all the oncological diseases detected in Russia 2020 and 21.7 tumors among women. The frequency brain metastases is estimated at 13–32 %. It known that HER2 positive triple negative breast cancers metastasize more frequently. Aim. To present case stereotactic high‑dose irradiation for a large brainstem metastasis from re‑irradiation recurrence. Materials methods. Analysis results recurrence with local control over five years was performed. Results. after did not show any signs tumor progression or post‑radiation necrosis. patient’s Karnofsky Performance Status 100 points. Conclusions. shows necessity highly conformal dose delivery tumor, precise determination boundaries on high resolution thin slice magnetic resonance imaging, verification using metabolic studies hypofractionated delivery. remains open whether what extent target therapy may contribute control.